What is cryopreservation and why does the -130°C threshold matter more than the storage temperature?
Most laboratory protocols specify liquid nitrogen storage at -195.8°C, but the biologically critical threshold is -130°C. Below this point, biological material enters a glassy state in which molecular movement effectively stops and enzymatic degradation cannot occur. Storage anywhere above -130°C — even briefly during a transfer or an alarm response — risks cellular damage that may not be immediately visible but compromises viability at thaw.
For IVF laboratories, this means the choice of cryogenic storage vessel is not just about capacity. Static evaporation rate, neck diameter, and lid seal integrity all determine how quickly the internal temperature rises during routine access. Cryolab supplies storage dewars and dry shippers specified for IVF cryopreservation, with full technical guidance on which configuration protects the -130°C threshold during real-world laboratory use. Contact Cryolab for equipment recommendations for your facility.
